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1 July 2000 Formation of nuclear HSF1 granules varies depending on stress stimuli
Carina I. Holmberg, Sara A. Illman, Marko Kallio, Andrey Mikhailov, Lea Sistonen
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Abstract

In concert with the stress-induced activation of human heat shock factor 1 (HSF1), the factor becomes inducibly phosphorylated and accumulates into nuclear granules. To date, these processes are not fully understood. Here, we show that although stress caused by the proteasome inhibitors MG132 and clasto-lactacystine β-lactone induces the expression of Hsp70, the formation of HSF1 granules is affected differently in comparison to heat shock. Furthermore, proteasome inhibition increases serine phosphorylation on HSF1, but to a lesser extent than heat stress. Our results suggest that, depending on the type of stress stimulus, the multiple events associated with HSF1 activation might be affected differently.

Carina I. Holmberg, Sara A. Illman, Marko Kallio, Andrey Mikhailov, and Lea Sistonen "Formation of nuclear HSF1 granules varies depending on stress stimuli," Cell Stress & Chaperones 5(3), 219-228, (1 July 2000). https://doi.org/10.1379/1466-1268(2000)005<0219:FONHGV>2.0.CO;2
Received: 25 January 2000; Accepted: 1 March 2000; Published: 1 July 2000
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