Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii-infected mice

Hye-Seong Mun; Fumie Aosai; Kazumi Norose; Mei Chen; Hidekazu Hata; Yoh-ichi Tagawa; Yoichi Iwakura; Dae-Seok Byun; Akihiko Yano

doi:10.1379/1466-1268(2000)005<0328:TGHAAD>2.0.CO;2

1 October 2000 Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii-infected mice

Hye-Seong Mun, Fumie Aosai, Kazumi Norose, Mei Chen, Hidekazu Hata, Yoh-ichi Tagawa, Yoichi Iwakura, Dae-Seok Byun, Akihiko Yano

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Cell Stress & Chaperones, 5(4):328-335 (2000). https://doi.org/10.1379/1466-1268(2000)005<0328:TGHAAD>2.0.CO;2

Abstract

Toxoplasma gondii Hsp70, T gondii Hsp30/bag1, and surface antigen 1 messenger RNAs were shown to be useful in analyzing stage conversion of T gondii between bradyzoites and tachyzoites. The high-level expression of T gondii Hsp70 was correlated with mortality in interferon-γ knockout mice infected with T gondii. T gondii Hsp70 inhibited the induction of nitric oxide release by peritoneal macrophages of T gondii-infected mice. These findings identify T gondii Hsp70 as a danger signal during lethal, acute T gondii infection.

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Hye-Seong Mun, Fumie Aosai, Kazumi Norose, Mei Chen, Hidekazu Hata, Yoh-ichi Tagawa, Yoichi Iwakura, Dae-Seok Byun, and Akihiko Yano "Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii-infected mice," Cell Stress & Chaperones 5(4), 328-335, (1 October 2000). https://doi.org/10.1379/1466-1268(2000)005<0328:TGHAAD>2.0.CO;2

Received: 30 March 2000; Accepted: 1 May 2000; Published: 1 October 2000

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