Ninety (64%) of 140 spoonhead sculpin, Cottus ricei (Nelson, 1876), collected in April, September, October, and November 2011 from 1 location near the Apostle Islands National Lakeshore of Lake Superior, Wisconsin were infected with Echinorhynchus salmonis (Muller, 1784) Petrochenko 1956. The overall mean intensity and mean abundance of E. salmonis in sculpins were 2.0 and 1.3, respectively. The proportions of infected sculpins and abundances of E. salmonis were significantly higher in each month of September, October, and November than in April 2011. Significant Spearman's rank correlation coefficients occurred between the intensities and abundances of E. salmonis and sculpin total length and wet weight. A total of 183 individuals of E. salmonis (98 females and 85 males) was counted in the infected sculpins. Of the female E. salmonis found, only 10 were gravid, and these occurred in sculpins in September, October, and November. Cottus ricei is a new host record for E. salmonis. Five undigested amphipods, Diporeia spp., were found infected with E. salmonis in the stomachs of sculpins. Echinorhynchus salmonis and other acanthocephalan species are common intestinal helminths of sculpin species (Cottus spp. and Myoxocephalus thompsonii) in the Great Lakes.