Exploration of the Iwokrama Forest in central Guyana resulted in the collection of two caecilians from the Cowfly Camp locality along the Iwokrama Mountain Trail. One specimen represents a new form that we describe as a diminutive new species of Microcaecilia. The second is an Epicrionops niger, a poorly known species from northern South America. We compare the Iwokrama specimen with literature accounts of E. niger and with three additional specimens collected elsewhere in Guyana. We also discuss the current taxonomy and distribution of the caecilians known from Guyana.