The indigenous people of Australia have a long and well-documented history of using native plants as an essential component of their customary economy. However, few have engaged successfully in commerce based on native plant use. Recently there has been an increasing interest in exploring options for use of native plants for food, food additives, botanical medicines, and related purposes. In this paper, we determine the issues important to Aboriginal people in enterprise development utilizing plant products, and we define some of the factors affecting progress in realizing opportunities. The Aboriginal people with whom we have worked appear to prefer small-scale enterprises where they have community ownership of ideas and control of the rate and direction of development. Government could play a larger and more active role through supporting additional research and marketing information, providing training, and better matching policy and legislation to support indigenous development and reduce dependence of welfare.