In Ethiopia, like that of the other developing countries, pesticides are widely used for a variety of purposes, but their unsafe use causes a major environmental and health hazard. The aim of this study was to assess pesticide use practice and its associated factors among the rural community of Malga district, Sidama region, southern Ethiopia. A community based cross-sectional study was conducted from February to March 2021 at Malga District. Data were collected from 549 farmers by a structured and pretested interviewer-administered questionnaire. Binary and multivariable logistic regression was used for the data analysis. Adjusted odds ratios and their 95% confidence intervals (CIs) were calculated to determine the association between safe practices of pesticide use and several related factors. Safe practice of pesticide use was observed in 193 (35.2%). The participants who had primary education [AOR = 5.605, 95% CI: 3.309, 9.495], secondary education and above [AOR = 9.847, 95% CI: 5.007, 19.368], used pesticide for 10 years and above [AOR = 6.790, 95% CI: 3.589, 12.843], used pesticide between 6 and 10 years [AOR = 1.913, 95% CI: 1.166, 3.141] pesticide bought from any shop [AOR = 2.320, 95% CI: 1.364, 3.947], agricultural office [AOR = 7.187, 95% CI: 3.654, 14.137] were associated with safe use of pesticides. The safe practice of pesticide use was low in the study area. Continuous training programs should be implemented on the safe practice of pesticide use to the local farmers.