From 242 collections 120 determined species representing 68 genera of lichens are reported from a two-day survey of privately owned and protected bluff and bottomland forests in Darlington and Florence Counties of South Carolina in May 2008. We also report a handful of specimens representing apparently undescribed species in the genera Arthonia, Melaspilea and Phaeographis. Two species of lichenicolous fungi, Sphinctrina tubiformis and Minutoexcipula tuckerae, are also reported (both from Pertusaria thalli). Species richness and composition suggests a healthy forest environment.