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1 April 2004 REPLICATION AT PERIODICALLY CHANGING MULTIPLICITY OF INFECTION PROMOTES STABLE COEXISTENCE OF COMPETING VIRAL POPULATIONS
Claus O. Wilke, Daniel D. Reissig, Isabel S. Novella
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Abstract

RNA viruses are widely used to study evolution experimentally. Many standard protocols of virus propagation and competition are done at nominally low multiplicity of infection (m.o.i.), but lead during one passage to two or more rounds of infection, of which the later ones are at high m.o.i. Here, we develop a model of the competition between wild type (wt) and a mutant under a regime of alternating m.o.i. We assume that the mutant is deleterious when it infects cells on its own, but derives a selective advantage when rare and coinfecting with wt, because it can profit from superior protein products created by the wt. We find that, under these assumptions, replication at alternating low and high m.o.i. may lead to the stable coexistence of wt and mutant for a wide range of parameter settings. The predictions of our model are consistent with earlier observations of frequency-dependent selection in vesicular stomatitis virus and human immunodeficiency virus type 1. Our results suggest that frequency-dependent selection may be common in typical evolution experiments with viruses.

Claus O. Wilke, Daniel D. Reissig, and Isabel S. Novella "REPLICATION AT PERIODICALLY CHANGING MULTIPLICITY OF INFECTION PROMOTES STABLE COEXISTENCE OF COMPETING VIRAL POPULATIONS," Evolution 58(4), 900-905, (1 April 2004). https://doi.org/10.1554/03-652
Received: 10 November 2003; Accepted: 18 November 2003; Published: 1 April 2004
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