MAJOR HISTOCOMPATIBILITY ALLELES ASSOCIATED WITH LOCAL RESISTANCE TO MALARIA IN A PASSERINE

Camille Bonneaud; Javier Pérez-Tris; Pierre Federici; Olivier Chastel; Gabriele Sorci

doi:10.1554/05-409.1

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1 February 2006 MAJOR HISTOCOMPATIBILITY ALLELES ASSOCIATED WITH LOCAL RESISTANCE TO MALARIA IN A PASSERINE

Camille Bonneaud, Javier Pérez-Tris, Pierre Federici, Olivier Chastel, Gabriele Sorci

Author Affiliations +

Camille Bonneaud,^1,2,3,* Javier Pérez-Tris,^4,5 Pierre Federici,^1,6 Olivier Chastel,^7,* Gabriele Sorci^1,**

¹aLaboratoire de Parasitologie Evolutive Centre National de la Recherche Scientifique UMR 7103, Paris
²bCentre d'Etude Biologique de Chizé, Centre National de la Recherche Scientifique UPR 1934, 79360 Vi
³dbonneaud@ucla.edu
⁴eDepartment of Animal Ecology, Lund University, SE-22362 Lund, Sweden
⁵fjavier.perez-tris@zooekol.lu.se
⁶gpierre.federici@snv.jussieu.fr
⁷hchastel@cebc.cnrs.fr

^*Present address: Center for Tropical Research, Institute of the Environment, University of California, Los Angeles, California 90095-1496
^**Present address: BioGéoSciences, Centre National de la Recherche Scientifique UMR 5561, Université de Bourgogne, 6 Boulevard Gabriel, 21000 Dijon, France; gsorci@snv.jussieu.fr

Evolution, 60(2):383-389 (2006). https://doi.org/10.1554/05-409.1

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Abstract

Malaria parasites are a major cause of human mortality in tropical countries and a potential threat for wildlife, as witnessed by the malaria-induced extinction of naive Hawaiian avifauna. Identifying resistance mechanisms is therefore crucial both for human health and wildlife conservation. Patterns of malaria resistance are known to be highly polygenic in both humans and mice, with marked contributions attributed to major histocompatibility (Mhc) genes. Here we show that specific Mhc variants are linked to both increased resistance and susceptibility to malaria infection in a wild passerine species, the house sparrow (Passer domesticus). In addition, links between host immunogenetics and resistance to malaria involved population-specific alleles, suggesting local adaptation in this host-parasite interaction. This is the first evidence for a population-specific genetic control of resistance to malaria in a wild species.

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Camille Bonneaud, Javier Pérez-Tris, Pierre Federici, Olivier Chastel, and Gabriele Sorci "MAJOR HISTOCOMPATIBILITY ALLELES ASSOCIATED WITH LOCAL RESISTANCE TO MALARIA IN A PASSERINE," Evolution 60(2), 383-389, (1 February 2006). https://doi.org/10.1554/05-409.1

Received: 21 July 2005; Accepted: 4 December 2005; Published: 1 February 2006

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Evolution

Evolution
Vol. 60 • No. 2
February 2006

KEYWORDS

avian malaria

local adaptation

major histocompatibility complex

resistance alleles

susceptibility alleles

wild passerine

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Camille Bonneaud, Javier Pérez-Tris, Pierre Federici, Olivier Chastel, Gabriele Sorci "MAJOR HISTOCOMPATIBILITY ALLELES ASSOCIATED WITH LOCAL RESISTANCE TO MALARIA IN A PASSERINE," Evolution, 60(2), 383-389, (1 February 2006)

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