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1 March 2006 PROPER CONTROL OF GENETIC BACKGROUND WITH PRECISE ALLELE SUBSTITUTION: A COMMENT ON COYNE AND ELWYN
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Abstract

Coyne and Elwyn report that, using Drosophila stocks provided by us, they were unable to replicate our experiments measuring the effects of desaturase-2 on stress tolerance. In this note, we provide evidence that these authors did not properly control for the differences in genetic background between the lines. Their experiments are thus not meaningful replications of our previous ones. We discuss ways of circumventing this problem in studies involving induced mutations in single genes.

Anthony J. Greenberg, Jennifer R. Moran, and Chung-I. Wu "PROPER CONTROL OF GENETIC BACKGROUND WITH PRECISE ALLELE SUBSTITUTION: A COMMENT ON COYNE AND ELWYN," Evolution 60(3), 623-625, (1 March 2006). https://doi.org/10.1554/05-173.1
Received: 29 March 2005; Accepted: 18 May 2005; Published: 1 March 2006
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