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1 October 2009 Genetic Analysis of Skull Shape Variation and Morphological Integration in the Mouse Using Interspecific Recombinant Congenic Strains between C57Bl/6 and Mice of the Mus spretus Species
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Abstract

To assess the genetic basis of the skull shape variation and morphological integration in mice, we have used a tool based on the cross between the distantly related mouse species Mus spretus (SEG/Pas strain) and the laboratory strain C57BL/6 called interspecific recombinant congenic strains (IRCSs). The genome of each IRCS consists on average of 1.3% of SEG/Pas derived sequences, located on multiple chromosomes as small-sized, DNA segments. Quantitative trait loci (QTL) on the skull shape, separated into dorsal and ventral sides, were analyzed in 17 IRCSs by a Procrustes superimposition method using 3D landmarks. The shapes of 16 strains differed significantly from C57BL/6. Discrepancy in the QTLs effects was found between the dorsal side and the anterior region of the ventral side due to a differential effect of the SEG/Pas alleles on the skull shape. A comprehensive analysis of all allelic combinations of the BCG-66H strain showed strong epistatic interactions between SEG/Pas segment acting on both skull sides. Epistatic pleiotropy and covariation between sides were dependent in SEG/Pas alleles direction and contributed to the strong morphological integration between sides. Introduction of Mus spretus alleles in a C57BL/6 background induced strong morphological changes mostly in SEG/Pas alleles direction and provided evidence for high level of morphological integration.

© 2009 The Society for the Study of Evolution.
Gaëtan Burgio, Michel Baylac, Evelyne Heyer, and Xavier Montagutelli "Genetic Analysis of Skull Shape Variation and Morphological Integration in the Mouse Using Interspecific Recombinant Congenic Strains between C57Bl/6 and Mice of the Mus spretus Species," Evolution 63(10), 2668-2686, (1 October 2009). https://doi.org/10.1111/j.1558-5646.2009.00737.x
Received: 6 October 2008; Accepted: 1 April 2009; Published: 1 October 2009
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