The Dominican Republic moss flora stands out within the Caribbean countries because of the high species richness and number of disjuncts. The flora is comprised of 467 taxa in 207 genera, and 61 families. We report 62 new records and 82 disjuncts for this flora that shows affinity with other Greater Antilles and Central America. Within the context of the Caribbean and in terms of conservation, this flora is important because it represents both the highest reported moss species richness and 82 unique disjuncts within the West Indies.