Hedyosmum guaramacalense, found in montane forest (1600–2600 m) on the south slope of Guaramacal National Park, Trujillo state, Venezuela, is described and illustrated. The new species belongs to H. subgenus Tafalla section Microcarpa and is similar to H. goudotianum var. goudotianum, but can be distinguished by its elliptic or narrowly elliptic, coriaceous or chartaceous leaves, scabrous above and below, with 5–8 lateral nerves; strigose or floccose petiolar sheaths with fimbriate appendages either restricted to two patches or evenly distributed along the apical margin; and staminate inflorescences in a cyme with 2–3 spikes, each spike 1–5 cm long. A key to the species of Hedyosmum currently known in the Venezuelan Andes also is provided.