Twenty new combinations were published in the Cactus and Succulent Journal between January 2004 and December 2006. Here we include the Latin diagnosis, holotype information and original citation for the following combinations that were published therein: Aloe alexandrei Ellert, Aloe irafensis Lavranos, McCoy & Gifri, Aloe koenenii Lavranos & K. Koch, Aloe orlandi Lavranos, Aloe pronkii Lavranos, Rakouth & McCoy, Antimima levynsiae (L. Bolus) S. A. Hammer, Bulbine erumpens S. A. Hammer, Drosanthemum anemophilum van Jaarsveld & S. A. Hammer, Echeveria cuspidata var gemmula Kimnach, Echeveria cuspidata var zaragozae Kimnach, Echeveria unguiculata Kimnach, Euphorbia bertemariae Dioli & Bisseret, Facheiroa braunii Esteves, Kalanchoe ×houghtonii D. B. Ward, Opuntia ×carstenii R. Puente & C. Hamann, Pachypodium mikea J. Lüthy, Pachypodium rosulatum ssp bemarahense J. Lüthy & Lavranos, Phyllobolus pearsonii N. E. Br. ex S. A. Hammer, Pilosocereus mollispinus P. J. Braun & Esteves and Rhytidocaulon arachnoideum McCoy.