Two new species of frogs of the Eleutherodactylus alfredi group are described from Subtropical and Montane Wet Forests of the Montañas del Mico and the Sierra de Caral of the Caribbean slopes of Guatemala. They differ from other Guatemalan species in the group by having the fifth toe pad wider than the second, few melanophores on the abdominal area of the venter, and dorsal and ventral ground coloration. The species from the Sierra de Caral is larger in overall size and has smaller dentigerous fascicules than the one from the Montañas del Mico. These two species also differ between themselves in dorsal and ventral ground coloration.