Effect of ACP1*C on Early Life Viability

F. Gloria-Bottini; N. Bottini; E. Bottini

doi:10.1353/hub.2006.0046

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F. Gloria-Bottini,^* N. Bottini,^** E. Bottini^*

^*Division of Biopathology of Human Populations and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy.
^**Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy.

Abstract

Associations with past malarial morbidity, season of conception, and common diseases such as obesity, type 2 diabetes, and allergy argue against neutrality of the ACP1 genetic polymorphism. Comparison of ACP1 distribution in mothers and their newborns and analysis of the joint wife-husband ACP1 phenotype distribution in couples with repeated spontaneous abortion suggest a negative effect of the ACP1*C allele on early life viability. Analysis of the polymorphism of the ACP1 gene suggests that, unlike the ACP1*A and ACP1*B alleles, the ACP1*C allele is independent of sequences in the 5′ flanking region, resulting in an inverted F/S isoform ratio.

Citation Download Citation

F. Gloria-Bottini, N. Bottini, and E. Bottini "Effect of ACP1*C on Early Life Viability," Human Biology 78(3), 365-369, (1 June 2006). https://doi.org/10.1353/hub.2006.0046

Received: 29 September 2005; Published: 1 June 2006

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