Translator Disclaimer
1 August 2013 Paternal Age and Genetic Load
Author Affiliations +
Abstract

The incidence of base substitutions in humans increases with the age of the father, which shows up as an increased incidence of mutational disorders in the children of older fathers. There is a less obvious implication: an extended period of high average paternal age in a population will lead to increased genetic load. We mention some societies that have had high average paternal age for many generations. This may explain some surprising regional differences in recent measurements of deleterious mutations. High average paternal age also influences life history evolution, strengthening selection against mortality in late life while weakening selection against child mortality.

© 2013 Wayne State University Press, Detroit, Michigan 48201–1309
Gregory Cochran and Henry Harpending "Paternal Age and Genetic Load," Human Biology 85(4), 515-528, (1 August 2013). https://doi.org/10.3378/027.085.0401
Received: 21 February 2013; Accepted: 1 May 2013; Published: 1 August 2013
JOURNAL ARTICLE
14 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top