MODELED MICROGRAVITY INHIBITS APOPTOSIS IN PERIPHERAL BLOOD LYMPHOCYTES1

DIANA RISIN; NEAL R. PELLIS

doi:10.1290/1071-2690(2001)037<0066:MMIAIP>2.0.CO;2

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1 February 2001 MODELED MICROGRAVITY INHIBITS APOPTOSIS IN PERIPHERAL BLOOD LYMPHOCYTES¹

DIANA RISIN, NEAL R. PELLIS

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In Vitro Cellular & Developmental Biology - Animal, 37(2):66-72 (2001). https://doi.org/10.1290/1071-2690(2001)037<0066:MMIAIP>2.0.CO;2

Abstract

Microgravity interferes with numerous lymphocyte functions (expression of cell surface molecules, locomotion, polyclonal and antigen-specific activation, and the protein kinase C activity in signal transduction). The latter suggests that gravity may also affect programmed cell death (PCD) in lymphocyte populations. To test this hypothesis, we investigated spontaneous, activation- and radiation-induced PCD in peripheral blood mononuclear cells exposed to modeled microgravity (MMG) using a rotating cell culture system. The results showed significant inhibition of radiation- and activation-induced apoptosis in MMG and provide insights into the potential mechanisms of this phenomenon.

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DIANA RISIN and NEAL R. PELLIS "MODELED MICROGRAVITY INHIBITS APOPTOSIS IN PERIPHERAL BLOOD LYMPHOCYTES¹," In Vitro Cellular & Developmental Biology - Animal 37(2), 66-72, (1 February 2001). https://doi.org/10.1290/1071-2690(2001)037<0066:MMIAIP>2.0.CO;2

Published: 1 February 2001

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