MECHANICAL FLUID FLOW AND SURFACTANT-TA INFLUENCE ACTIVATION OF MACROPHAGES

YOSHINORI MITA; KUNIO DOBASHI; TSUGIO NAKAZAWA; MASATOMO MORI

doi:10.1290/1071-2690(2001)037<0270:MFFAST>2.0.CO;2

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1 May 2001 MECHANICAL FLUID FLOW AND SURFACTANT-TA INFLUENCE ACTIVATION OF MACROPHAGES

YOSHINORI MITA, KUNIO DOBASHI, TSUGIO NAKAZAWA, MASATOMO MORI

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In Vitro Cellular & Developmental Biology - Animal, 37(5):270-274 (2001). https://doi.org/10.1290/1071-2690(2001)037<0270:MFFAST>2.0.CO;2

Abstract

We examined the effect of mechanical fluid flow and surfactant on macrophage aggregation as the indication of macrophage activation. Mechanical fluid flow enhanced aggregation in phorbol myristate acetate (PMA)-treated human myeloid leukemic cell lines (HL-60 cells), but had no effect on differentiation of PMA-treated HL-60 cells. Surfactant-TA (an artificial surfactant) inhibited fluid flow–induced aggregation, but had no effect on differentiation of PMA-treated HL-60 cells. Human alveolar macrophages spontaneously formed small aggregates without stimulation. This aggregation was enhanced by fluid flow and inhibited by surfactant-TA. Taken together, these data suggest that macrophage activation is affected by fluid flow and surfactants.

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YOSHINORI MITA, KUNIO DOBASHI, TSUGIO NAKAZAWA, and MASATOMO MORI "MECHANICAL FLUID FLOW AND SURFACTANT-TA INFLUENCE ACTIVATION OF MACROPHAGES," In Vitro Cellular & Developmental Biology - Animal 37(5), 270-274, (1 May 2001). https://doi.org/10.1290/1071-2690(2001)037<0270:MFFAST>2.0.CO;2

Received: 25 January 2000; Accepted: 1 January 2001; Published: 1 May 2001

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