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1 January 2003 TASTE RECEPTOR T1R3 IS AN ESSENTIAL MOLECULE FOR THE CELLULAR RECOGNITION OF THE DISACCHARIDE TREHALOSE
TOSHIO ARIYASU, SHUJI MATSUMOTO, FUMIYO KYONO, TOSHIHARU HANAYA, SHIGEYUKI ARAI, MASAO IKEDA, MASASHI KURIMOTO
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Abstract

Recently, a sweet taste receptor family, the T1R family, that recognizes some carbohydrates including sucrose was identified. Although the T1R3 molecule is known to participate in heterodimers that are used as sweet- and umami-tasting receptors, there is no evidence that T1R3 alone recognizes similar ligands. We demonstrate for the first time that the candidate sweet taste receptor T1R3 is essential for the recognition and response to the disaccharide trehalose. Our system is a valuable tool not only for understanding the relationship between sweeteners and their receptors but also for exploring the diversities of their receptors, resulting in the design of new high-potency sweeteners.

TOSHIO ARIYASU, SHUJI MATSUMOTO, FUMIYO KYONO, TOSHIHARU HANAYA, SHIGEYUKI ARAI, MASAO IKEDA, and MASASHI KURIMOTO "TASTE RECEPTOR T1R3 IS AN ESSENTIAL MOLECULE FOR THE CELLULAR RECOGNITION OF THE DISACCHARIDE TREHALOSE," In Vitro Cellular & Developmental Biology - Animal 39(1), 80-88, (1 January 2003). https://doi.org/10.1290/1543-706X(2003)039<0080:TRTIAE>2.0.CO;2
Received: 18 February 2003; Accepted: 12 March 2003; Published: 1 January 2003
JOURNAL ARTICLE
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KEYWORDS
carbohydrates
G protein–coupled receptors
intracellular calcium
sweetener
T1Rs
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