Translator Disclaimer
1 March 2005 ACTIVATION OF NUCLEAR TRANSCRIPTION FACTOR–κB IN MOUSE BRAIN INDUCED BY A SIMULATED MICROGRAVITY ENVIRONMENT
KIMBERLY C. WISE, SUNIL K. MANNA, KEIKO YAMAUCHI, VANI RAMESH, BOBBY L. WILSON, RENARD L. THOMAS, SHUBHASHISH SARKAR, ANIL D. KULKARNI, NEIL R. PELLIS, GOVINDARAJAN T. RAMESH
Author Affiliations +
Abstract

Microgravity induces inflammatory responses and modulates immune functions that may increase oxidative stress. Exposure to a microgravity environment induces adverse neurological effects; however, there is little research exploring the etiology of these effects resulting from exposure to such an environment. It is also known that spaceflight is associated with increase in oxidative stress; however, this phenomenon has not been reproduced in land-based simulated microgravity models. In this study, an attempt has been made to show the induction of reactive oxygen species (ROS) in mice brain, using ground-based microgravity simulator. Increased ROS was observed in brain stem and frontal cortex with concomitant decrease in glutathione, on exposing mice to simulated microgravity for 7 d. Oxidative stress–induced activation of nuclear factor–kappaB was observed in all the regions of the brain. Moreover, mitogen-activated protein kinase kinase was phosphorylated equally in all regions of the brain exposed to simulated microgravity. These results suggest that exposure of brain to simulated microgravity can induce expression of certain transcription factors, and these have been earlier argued to be oxidative stress dependent.

KIMBERLY C. WISE, SUNIL K. MANNA, KEIKO YAMAUCHI, VANI RAMESH, BOBBY L. WILSON, RENARD L. THOMAS, SHUBHASHISH SARKAR, ANIL D. KULKARNI, NEIL R. PELLIS, and GOVINDARAJAN T. RAMESH "ACTIVATION OF NUCLEAR TRANSCRIPTION FACTOR–κB IN MOUSE BRAIN INDUCED BY A SIMULATED MICROGRAVITY ENVIRONMENT," In Vitro Cellular & Developmental Biology - Animal 41(3), 118-123, (1 March 2005). https://doi.org/10.1290/0501006.1
Received: 26 January 2005; Accepted: 11 April 2005; Published: 1 March 2005
JOURNAL ARTICLE
6 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

Share
SHARE
KEYWORDS
glutathione
hindlimb unloading
MAPKK
reactive oxygen species of NF-κB
simulated microgravity
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top