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24 October 2007 Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-60
Tomomi Date, Susumu Mitsutake, Yasuyuki Igarashi
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Abstract

Ceramide kinase (CerK) has important roles in leukocyte functions, including the role in degranulation of mast cells and the phagocytosis of polymorphonuclear leukocytes, so its expression levels should be strictly regulated. Here, we report that the mRNA expression and enzyme activity of CerK were decreased during macrophage-like cell differentiation of the leukemia cell line HL-60, yet neither was altered during granulocytic differentiation of the same cells. Our findings demonstrate that HL-60 cells are useful for studying CerK functions in leukocyte differentiation, and they also suggest that CerK might have an important role in such differentiation.

Tomomi Date, Susumu Mitsutake, and Yasuyuki Igarashi "Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-60," In Vitro Cellular & Developmental Biology - Animal 43(10), 321-323, (24 October 2007). https://doi.org/10.1007/s11626-007-9063-z
Received: 28 August 2007; Accepted: 26 September 2007; Published: 24 October 2007
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