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6 November 2007 Adult rat bone marrow stromal cells differentiate into Schwann cell-like cells in vitro
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Abstract

Bone marrow stromal cells (MSCs) have the capability of differentiating into mesenchymal and non-mesenchymal lineages. In this study, MSCs isolated from adult Sprague-Dawley rats were cultured to proliferation, followed by in vitro induction under specific conditions. The results demonstrated that MSCs were transdifferentiated into cells with the Schwann cell (SC) phenotypes according to their morphology and immunoreactivities to SC surface markers including S-100, glial fibrillary acidic protein (GFAP) and low-affinity nerve growth factor receptor (p75). Consequently, rat adult MSCs can be induced in vitro to differentiate into SC-like cells, thus developing an abundant and accessible SC reservoir to meet the requirements of constructing tissue engineered nerve grafts for peripheral nerve repair.

Wei Wei Lin, Xue Chen, Xiao Dong Wang, Jie Liu, and Xiao Song Gu "Adult rat bone marrow stromal cells differentiate into Schwann cell-like cells in vitro," In Vitro Cellular & Developmental Biology - Animal 44(1), 31-40, (6 November 2007). https://doi.org/10.1007/s11626-007-9064-y
Received: 22 January 2007; Accepted: 14 September 2007; Published: 6 November 2007
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