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1 December 2003 Pharmacokinetics of Marbofloxacin After Oral Administration to Eurasian Buzzards (Buteo buteo)
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Marbofloxacin is a bactericidal fluoroquinolone developed exclusively for veterinary medicine. The pharmacokinetic disposition of this drug was studied after oral administration of a single dose (10 mg/kg) to 8 adult Eurasian buzzards (Buteo buteo). Plasma concentrations of marbofloxacin were measured during the 48-hour period after drug administration. A maximum plasma concentration of 3.70 μg/ml was achieved at 2.92 hours. Marbofloxacin was relatively slowly absorbed after oral administration (absorption half-life of 1.57 hours) and demonstrated a high bioavailability (92.15%). The elimination half-life was 9.48 hours, and the mean residence time was 10.65 hours. When using a minimum inhibitory concentration (MIC) breakpoint of 0.25 μg/ml, the calculated antimicrobial efficacy of orally administered marbofloxacin was higher than the range considered optimal for a dosing regimen against pathogens with an equivalent MIC. A dosage of 10 mg/kg administered once daily appears to be appropriate for the treatment of most infections with gram-negative bacteria that affect Eurasian buzzards.

Marino García-Montijano, Fernando González, Samanta Waxman, Celia Sánchez, J. Julio de Lucas, Manuel San Andrés, and Casilda Rodríguez "Pharmacokinetics of Marbofloxacin After Oral Administration to Eurasian Buzzards (Buteo buteo)," Journal of Avian Medicine and Surgery 17(4), 185-190, (1 December 2003).
Published: 1 December 2003

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