A 2-yr field study was conducted to evaluate a botanical natural product, AkseBio2, for control of pear psylla, Cacopsylla pyri L. (Homoptera: Psyllidae). Three applications were made each year. Whereas the first application was applied at the dormant period (just before the first eggs were deposited by overwintered females), the second and third applications, respectively, were against the first and second summer generations of pear psylla. The first application deterred winterform females from depositing eggs until the clusterbud stage (buds expanded but no blossoms open) of tree development. In the second and third applications, the product reduced the number of psyllid eggs and young (first and second) instars, causing up to 79.4 and 81.1% mortality, respectively. However, it was less active against the older (third–fifth) instars and achieved only up to 52.7% mortality. Reduction in egg laying was greater than that caused by amitraz, the most commonly used conventional pesticide for psylla control in Turkey. There were no significant horticultural changes on treated plants up to 7 d after treatment in any trial, nor was there any phytotoxicity on plant tissue as a result of AkseBio2 treatments.