Field studies were conducted in 2003 and 2004 to determine the effects of grassy weeds, postemergence grass control, transgenic rootworm-resistant corn, Zea mays L., expressing the Cry3Bb1 endotoxin and glyphosate herbicide tolerance (Bt corn), and the interactions of these factors on western corn rootworm, Diabrotica virgifera virgifera LeConte, damage and adult emergence. Three insect management tactics (Bt corn, its nontransgenic isoline, and isoline plus tefluthrin) were evaluated with two weed species (giant foxtail, Setaria faberi Herrm, and large crabgrass, Digitaria sanquinalis L. Scop), and four weed management regimes (weed free, no weed management, early [V3–4] weed management and late [V5–6] weed management) in a factorial arrangement of a randomized split split-plot design. In each case, the isoline was also tolerant to glyphosate. Root damage was significantly affected by insect management tactics in both years, but weed species and weed management did not significantly affect damage to Bt corn in either year. Adult emergence was significantly affected by insect management tactics in both years and by weed species in 2003, but weed management and the interaction of all three factors was not significant in either year. The sex ratio of female beetles produced on Bt corn without weeds was generally greater than when weeds were present and this difference was significant for several treatments each year. Average dry weight of male and female beetles emerging from Bt corn was greater than the weights of beetles emerging from isoline or isoline plus tefluthrin in 2003, but there was no difference for females in 2004 and males weighed significantly less than other treatments in 2004. The implications of these results in insect resistance management are discussed.