New pesticides are required to maintain effective resistance management strategies for control of western flower thrips, Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae). We tested the efficacy of acetamiprid, and thiamethoxam, two neonicotinoids that represent a newer class of insecticides for the control of thrips. We also tested chlorfenapyr, a pyrrol compound, and a lower than registered rate of the biopesticide spinosad. Laboratory bioassays were used to predict the relative efficacy of insecticides against F. occidentalis and to forecast likely field rates. Two doses within the calculated LC_99.99 range were used to predict field rates and trial rates of 0.5 g and 1.0 active ingredient (AI)/liter acetamiprid, 0.025 and 0.05g (AI)/liter chlorfenapyr, 0.3 and 0.6g (AI)/literthiamethoxam, and 0.01 g (AI)/liter spinosad were tested in the greenhouse against pepper, lettuce, and tomato. With the exception of acetamiprid, field trial doses predicted from laboratory bioassay translated to effective field efficacy. All products controlled F. occidentalis at the rates trialed and so have potential to augment current chemical controls. Increasing mortality correlated with increasing acetamiprid concentration in a greenhouse lettuce trial, suggesting that the higher trial rate (1.0 g [AI]/liter) may be required in some lettuce crops. The lower than registered (0.01 g [AI]/liter) rate of spinosad also significantly reduced F. occidentalis numbers and is a viable control option that may be useful in specific integrated pest management programs. The implications of introducing neonicotinoids into existing insecticide resistance management strategies for F. occidentalis are discussed.