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1 April 2009 A Sustained Release Gel Formulation of Doramectin for Control of Lone Star Ticks (Acari: Ixodidae) and Horn Flies (Diptera: Muscidae) on Cattle
K. H. Lohmeyer, J. A. Miller, J. M. Pound, J. A. Klavons
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Abstract

A gel formulation formed by incorporating technical doramectin into a 10% hydroxypropyl methylcellulose aqueous solution was used to subcutaneously inject steers at varying dosages. Doramectin serum concentration of steers receiving 600 µg (AI)/kg body weight declined from 21.9 ppb at 0.5 wk to below detectable at 8 wk postinjection. The 1,200 µg (AI)/kg injection resulted in serum concentrations of 29.1 ppb at 0.5 wk and declined to 0.5 ppb at 8 wk postinjection. Both the 600 and 1,200 µg (AI)/kg injections provided 100% inhibition of index of fecundity (IF) in adult lone star ticks, Amblyomma americanum L. (Acari: Ixodidae) through week 8, after which inhibition declined to 79.4 and 45.3%, respectively, during the 12th week posttreatment. For steers treated at 600 µg (AI)/kg, mortality of adult horn flies, Hematobia irritans L. (Diptera: Muscidae), declined from 16.9% during week 2 to 3.1% during week 7 postinjection. The blood from steers treated at 1,200 µg (AI)/kg resulted in a similar decline in mortality of blood fed adult horn flies from 29.4% during week 1 to 4.0% during week 7. The 600 µg (AI)/kg treatment provided complete control of larval horn flies in the manure for 9 wk, whereas the 1,200 µg (AI)/kg injection gave complete control for 14 wk posttreatment. The doramectin gel formulation provided long-lasting delivery of doramectin to cattle and extended control of lone star ticks and larval horn flies. Such a simple and inexpensive formulation could be useful in tick eradication programs by reducing the frequency of gathering cattle.

K. H. Lohmeyer, J. A. Miller, J. M. Pound, and J. A. Klavons "A Sustained Release Gel Formulation of Doramectin for Control of Lone Star Ticks (Acari: Ixodidae) and Horn Flies (Diptera: Muscidae) on Cattle," Journal of Economic Entomology 102(2), 804-808, (1 April 2009). https://doi.org/10.1603/029.102.0243
Received: 28 August 2008; Accepted: 1 December 2008; Published: 1 April 2009
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