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12 June 2017 Identification of Potential Helicoverpa armigera (Lepidoptera: Noctuidae) Sterol Carrier Protein-2 Inhibitors Through High-Throughput Virtual Screening
Jun Cai, Xinkai Du, Changgao Wang, Jianguo Lin, Xin Du
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Abstract

Helicoverpa armigera sterol carrier protein-2 (HaSCP-2) is a validated target for development of novel insecticides due to its divergent protein structure and function from the vertebrate SCP-2. HaSCP-2 is important for normal development and fertility in Helicoverpa armigera (Hübner). The discovery of chemical inhibitors of HaSCP-2 through a structure-based virtual screening is reported here. Bioassay indicated that H1 and H14 had inhibitory effect on the growth of H. armigera larvae. The results suggest that H1 and H14 are promising as useful lead compounds for further optimization and development of novel SCP-2-specific pesticides.

© The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com
Jun Cai, Xinkai Du, Changgao Wang, Jianguo Lin, and Xin Du "Identification of Potential Helicoverpa armigera (Lepidoptera: Noctuidae) Sterol Carrier Protein-2 Inhibitors Through High-Throughput Virtual Screening," Journal of Economic Entomology 110(4), 1779-1784, (12 June 2017). https://doi.org/10.1093/jee/tox157
Received: 1 March 2017; Accepted: 13 May 2017; Published: 12 June 2017
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