The invasive sugarcane aphid, Melanaphis sacchari (Zehntner), is a devastating new pest of grain sorghum. Studies were conducted utilizing an integrated approach of four management tactics: planting date, insecticidal seed treatment, a foliar-applied insecticide, and plant resistance. Experiments were conducted in 2016 and 2017 at Griffin, Tifton, and Plains Georgia, and in 2016 in Texas, Alabama, and Oklahoma, United States. Early planting was effective in reducing damage and increasing yields when compared to the late planting. Use of a resistant variety reduced cumulative aphid-days, plant injury and usually prevented significant yield loss. Foliar application of flupyradifurone when aphids reached an economic threshold, was an effective management tactic preventing aphid injury and yield loss. Use of clothianidin seed treatment also reduced aphid injury and yield loss of the susceptible hybrid but generally did not prevent injury and yield loss of the resistant hybrid. We conclude that an earlier planting date coupled with a resistant variety and judicious use of an efficacious foliar-applied insecticide can effectively manage sugarcane aphid on grain sorghum. An insecticide seed treatment also may be useful to reduce the risk of sugarcane aphid damage to seedlings of susceptible hybrids.