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1 December 2001 Isolation of a Deet-Insensitive Mutant of Drosophila melanogaster (Diptera: Drosophilidae)
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Abstract

Despite the widespread use of N,N,-diethyl-3-methylbenzamide (deet) in insect repellent products, nothing is known about the molecular basis for the repellency of deet. We initiated a molecular genetics program to elucidate the molecular mechanism of deet repellency in Drosophila melanogaster (Meigen). Deet repellency was apparently due to airborne vapors, as wild type flies were repelled by a deet-treated surface in the absence of physical contact and in the dark. A mutant was isolated using chemical mutagenesis and a choice assay. In a choice assay, mutant flies entered 82 ± 1% of deet-containing tubes, whereas wild type flies entered only 6 ± 2% of deet-containing tubes. The mutant was repelled by other repellents, benzaldehyde and citronellal. The mutation was recessive and located on the X chromosome.

Nancy L. Reeder, Philip J. Ganz, John R. Carlson, and Charles W. Saunders "Isolation of a Deet-Insensitive Mutant of Drosophila melanogaster (Diptera: Drosophilidae)," Journal of Economic Entomology 94(6), 1584-1588, (1 December 2001). https://doi.org/10.1603/0022-0493-94.6.1584
Received: 14 February 2001; Accepted: 1 July 2001; Published: 1 December 2001
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