Although nonsteroidal anti-inflammatory drugs (NSAIDs) are often used in anurans, limited pharmacodynamic data are available regarding their value, particularly with regards to repeated dosing. This study investigated the efficacy and safety of serial, once-daily NSAID dosing in smoky jungle frogs (Leptodactylus pentadactylus). Twenty frogs were randomly assigned to receive one of five treatments, once daily for six consecutive days: topical diclofenac (1 mg/kg) or subcutaneous firocoxib (5 mg/kg), ketoprofen (1 mg/kg), meloxicam (0.2 mg/kg), or an equal volume 0.9% saline (control). An acetic acid test was used to determine the nociceptive threshold for each frog 2, 8, 24, 48, and 144 h after initial drug administration. All frogs were euthanized on day 7 for gross examination and histopathology. No significant difference in response was noted for any drug at any time point compared with saline. Mean or median test response for NSAID groups was greater than or equal to saline in 3/4, 2/4, 4/4, 4/4, and 3/4 frogs at 2, 8, 24, 48, and 144 h, respectively. Significant necropsy findings included epidermal necrosis of the hindlimbs in 7/20 frogs (NSAID groups), gastric ulceration in 6/ 20 frogs (NSAID and saline groups), and renal tubular degeneration in 1/20 frogs (NSAID group). None of the aforementioned pathologies were suspected to be secondary to NSAID administration. Further research regarding NSAID pharmacokinetics and pharmacodynamics in anurans is warranted. Topical acetic acid is correlated with epidermal necrosis in smoky jungle frogs.
You have requested a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Neither BioOne nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations.
Translations are not retained in our system. Your use of this feature and the translations is subject to all use restrictions contained in the Terms and Conditions of Use of the BioOne website.