A 39-yr-old intact adult female Yacare caiman (Caiman yacare) presented with hindlimb paresis. Magnetic resonance imaging and computed tomography studies revealed a compressive vertebral mass in the lumbar spine associated with a large left pelvic osseous mass and multiple extensive osteolytic lesions in both the axial and appendicular skeletons. Because of the severity and extension of the osseous lesions, euthanasia was elected. Gross necropsy findings included bilateral, hardened, irregular ovaries and multifocal pale, thickened bone marrow. Histopathologic findings were consistent with an ovarian carcinoma with metastasis to the pelvis, vertebrae, and femurs. Reproductive neoplasms with skeletal metastasis should be added to the differential diagnoses for nonspecific progressive and chronic wasting or lameness in intact aging crocodilians.