Oxytetracycline (42 mg/kg SC q6d) was injected into the dorsal shoulder region of 29 sea turtles during clinical management after stranding, including 10 Kemp's ridley (Lepidochelys kempii), 10 loggerhead (Caretta caretta), and nine green sea turtles (Chelonia mydas). Before injection, the drug was diluted into a suitable fluid for injection (5–20 ml/kg) as chosen by the attending veterinarian. Turtles were treated for as long as clinically indicated prior to discontinuing the drug (range 2–10 doses, median four). After the final injection, blood was collected at 1, 2, 4, 8, 72, 144, and 288 h and plasma harvested for measurement of the oxytetracycline plasma concentration. To limit the volume of blood collected, a sparse sampling strategy was used with samples collected at only three or four time points per turtle. The plasma oxytetracycline concentration was measured with high pressure liquid chromatography. Population pharmacokinetics using nonlinear mixed effects modeling produced the following results: half-life, 36 h; volume of distribution, 0.78 L/kg; and area-under-the-curve, 2,799 µg*h/ml. Using this dose and method of administration, the plasma oxytetracycline concentrations were maintained above a minimum inhibitory concentration value of approximately 4 µg/ml for approximately 6 days.
You have requested a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Neither BioOne nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations.
Translations are not retained in our system. Your use of this feature and the translations is subject to all use restrictions contained in the Terms and Conditions of Use of the BioOne website.