Liver disease is prevalent in reptiles, but the understanding of the secondary consequences of liver disease in reptile patients is far from understood. This case series details three lizards that developed coagulopathy secondary to hepatopathies. Two green iguanas (Iguana iguana), both diagnosed with severe hepatic fibrosis, experienced coagulopathies—one with fatal exsanguination from a broken toenail and the second with acute pulmonary hemorrhage. A Mali uromastyx (Uromastyx maliensis) diagnosed with severe hepatic lipidosis experienced acute severe respiratory distress secondary to acute tracheal hemorrhage. The occurrence of pulmonary or tracheal hemorrhage in two patients appears notable; however, more cases are needed to determine the significance of this finding. All three cases had hepatopathies diagnosed by computed tomography, prior to the coagulation-related complications. Based upon the cases presented here, it is recommended that coagulopathic sequelae of liver disease be considered in lizards with hepatopathies.