In mammals, both maternal and paternal genomes are required to accomplish normal development to term, because parent-specific epigenetic modification of the genome is imposed during gametogenesis. This leads to inequivalent expression of imprinted genes sorely from the maternal and paternal allele. Production of a viable parthenogenetic mouse individual proved that genomic imprinting governs mammalian ontogeny.
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Vol. 22 • No. 2