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1 March 2006 Significance of Mammalian Cumulus-Oocyte Complex Matrix in Oocyte Meiotic Maturation: Review of the Synthetic Control and Possible Roles of Hyaluronan (HA) and HA-binding Protein
Naoko Kimura, Kiyoshi Totsukawa, Eimei Sato
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Abstract

In most mammals, the growth and development of the oocyte and its surrounding somatic cell compartment in the follicle occur in a highly coordinated and mutually dependent manner. Oocytes acquire developmental competence sequentially during follicle growth, finally gaining the ability to undergo complete meiotic and cytoplasmic maturation at the final stage of the preovulatory follicle. Fully-grown immature oocytes are tightly surrounded by compact layers of specialized granulosa cells called cumulus cells that form the cumulus-oocyte complex (COC). After a preovulatory surge of gonadotrophin, the cumulus cells organize a special muco-elastic extracellular matrix (ECM) that requires synthesis and deposition of a large amount of hyaluronan (HA) and HA-binding matrix glycoproteins. Many studies have reported that the formation of the COC matrix mass plays important roles in a variety of reproductive phenomenons: oocyte meiotic maturation with changes of junctional communication and cytoskeletal modification in COC, ovulation, fertilization and early embryo development. Recently, we identified the expressions of HA synthases and the HA receptor, CD44, in the porcine COC matrix. The interaction of HA and CD44 appears to be closely related to gap-junctional communications and meiotic resumption during oocyte maturation. This review describes the recent findings on the regulation and the presumptive mechanism of COC matrix molecules, and physiological features in COC expansion.

Naoko Kimura, Kiyoshi Totsukawa, and Eimei Sato "Significance of Mammalian Cumulus-Oocyte Complex Matrix in Oocyte Meiotic Maturation: Review of the Synthetic Control and Possible Roles of Hyaluronan (HA) and HA-binding Protein," Journal of Mammalian Ova Research 23(1), 36-51, (1 March 2006). https://doi.org/10.1274/jmor.23.36
Received: 12 October 2005; Accepted: 1 December 2005; Published: 1 March 2006
JOURNAL ARTICLE
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KEYWORDS
CD44
cumulus expansion
cumulus-oocyte complex
hyaluronan
Oocyte meiotic maturation
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