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1 April 2007 Uterine Angiogenesis during Implantation in Mice
Hiromichi Matsumoto, Emiko Fukui, Midori Yoshizawa
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Abstract

Increased uterine vascular permeability and angiogenesis are hallmarks of implantation and placentation. These events are profoundly influenced by vascular endothelial growth factor (VEGF). Although VEGF and its receptor Flk-1 are primarily important for uterine vascular permeability and angiogenesis before and during the attachment phase of the implantation process, VEGF together with the angiopoietins and their receptor Tie-2 directs angiogenesis during decidualization after implantation. Upstream of VEGF, estrogen promotes uterine vascular permeability but inhibits angiogenesis, whereas progesterone stimulates angiogenesis with little effect on vascular permeability. Furthermore, COX-2-derived prostaglandins participate in uterine vascular permeability and angiogenesis during implantation and decidualization.

Hiromichi Matsumoto, Emiko Fukui, and Midori Yoshizawa "Uterine Angiogenesis during Implantation in Mice," Journal of Mammalian Ova Research 24(2), 45-49, (1 April 2007). https://doi.org/10.1274/jmor.24.45
Published: 1 April 2007
JOURNAL ARTICLE
5 PAGES

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KEYWORDS
angiogenesis
implantation
uterus
Vascular permeability
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