In ICSI, sperm is selected based on its motility and shape under 200–400× magnification. However, sperm morphology, especially the existence of vacuoles, may relate to sperm nuclear DNA fragmentation. Bartoov et al. reported the application of sperm selection under high (1,000–6,000×) magnification, which they referred to as IMSI (intracytoplasmic morphologically-selected sperm injection). In our initial trials, the fertilization, blastocyst development, pregnancy and miscarriage rates of 115 single blastocyst transfer cycles with IMSI or ICSI were 84.0% vs. 75.5%, 47.5% vs. 43.7%, 50.0% vs. 47.4% and 10.0% vs. 11.0%, respectively. Further studies are required to establish the systems and clarify the indications for IMSI.
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1 October 2008
Outcome of ICSI with Morphologically Selected Spermatozoa
Yasushi Odawara,
Takeshi Hosaka,
Noriko Yoshii,
Tomoko Kudo,
Akane Abe,
Satoshi Akimoto,
Nobuyoshi Takeda
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Journal of Mammalian Ova Research
Vol. 25 • No. 4
October 2008
Vol. 25 • No. 4
October 2008
ICSI
IMSI
Male infertility
Morphologically sellected sperm injection
Oligozoospermia