Tumor Protein p53 Gene Polymorphism and Developmental Competence of Embryos Derived from in Vitro Fertilization in Old-aged and Long-term Infertile Japanese Black Cows

Tomoko Yuzawa; Emiko Fukui; Hiromichi Matsumoto; Tomohiro Kawada; Akio Kawanobe; Kazutaka Niira; Masanori Ochi; Midori Yoshizawa

doi:10.1274/jmor.28.75

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1 April 2011 Tumor Protein p53 Gene Polymorphism and Developmental Competence of Embryos Derived from in Vitro Fertilization in Old-aged and Long-term Infertile Japanese Black Cows

Tomoko Yuzawa, Emiko Fukui, Hiromichi Matsumoto, Tomohiro Kawada, Akio Kawanobe, Kazutaka Niira, Masanori Ochi, Midori Yoshizawa

Author Affiliations +

Tomoko Yuzawa,^1,2 Emiko Fukui,^1,2 Hiromichi Matsumoto,^1,2 Tomohiro Kawada,³ Akio Kawanobe,⁴ Kazutaka Niira,⁴ Masanori Ochi,⁵ Midori Yoshizawa^1,2,*

¹1United Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-80
²2Laboratory of Animal Breeding and Reproduction, Faculty of Agriculture, Utsunomiya University, Utsu
³3Tochigi Prefecture Livestock Experiment Station, Tochigi 321-3303, Japan
⁴4Tochigi Prefecture Dairy Experimental Institute, Tochigi 329-2724, Japan
⁵5Ochi Yume Clinic Nagoya, Nagoya 460-0002, Japan

^*To whom correspondence should be addressed. e-mail: midoriy@cc.utsunomiya-u.ac.jp

J. of Mammalian Ova Research, 28(1):75-78 (2011). https://doi.org/10.1274/jmor.28.75

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Abstract

The present study analyzed tumor protein p53 gene (TP53) polymorphism as a factor in uterine implantation and establishment of pregnancy in four old-aged Japanese Black cows with long-term infertility. They had G allele or A allele in exon 6 of the gene. Oocytes were collected from these females using ovum pick up (OPU) and fertilized in vitro. Only some of the oocytes from individuals having G allele had developmental competence to the blastocyst stage, while no oocytes having the A allele had the competence to develop to the blastocyst stage. In conclusion, we suggest that a cause of long-term infertility in old-aged Japanese Black cows may be a polymorphism of TP53 affecting the competence of embryonic development.

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Tomoko Yuzawa, Emiko Fukui, Hiromichi Matsumoto, Tomohiro Kawada, Akio Kawanobe, Kazutaka Niira, Masanori Ochi, and Midori Yoshizawa "Tumor Protein p53 Gene Polymorphism and Developmental Competence of Embryos Derived from in Vitro Fertilization in Old-aged and Long-term Infertile Japanese Black Cows," Journal of Mammalian Ova Research 28(1), 75-78, (1 April 2011). https://doi.org/10.1274/jmor.28.75

Received: 1 September 2010; Accepted: 1 October 2010; Published: 1 April 2011

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Journal of Mammalian Ova Research
Vol. 28 • No. 1
April 2011

KEYWORDS

Cow

in vitro fertilization

Infertile

Japanese Black

TP53

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Tomoko Yuzawa, Emiko Fukui, Hiromichi Matsumoto, Tomohiro Kawada, Akio Kawanobe, Kazutaka Niira, Masanori Ochi, Midori Yoshizawa "Tumor Protein p53 Gene Polymorphism and Developmental Competence of Embryos Derived from in Vitro Fertilization in Old-aged and Long-term Infertile Japanese Black Cows," Journal of Mammalian Ova Research, 28(1), 75-78, (1 April 2011)

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