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1 October 2016 DNA Methylation Dynamics During Early Human Development
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Abstract

DNA methylation is essential for normal mammalian development and plays critical roles in various biological processes, including genomic imprinting, X-chromosome inactivation and repression of transposable elements. Although DNA methylation patterns are relatively stable in somatic cells, global reprogramming of DNA methylation occurs during mammalian preimplantation development. Advances in DNA methylation profiling techniques have been revealing the DNA methylation dynamics in mammalian embryos. Recently, we and other groups reported genome-scale DNA methylation analyses of human oocytes and preimplantation embryos, highlighting both the similarities and differences in the DNA methylation dynamics between humans and mice. In this review, we introduce the current knowledge of DNA methylation dynamics during early mammalian development. We also discuss the possibility of the application of genome-scale DNA methylation analysis techniques to human gametes and embryos for diagnostic purposes.

©2016 Japan Society for Ova Research
Hiroaki Okae and Takahiro Arima "DNA Methylation Dynamics During Early Human Development," Journal of Mammalian Ova Research 33(2), 101-107, (1 October 2016). https://doi.org/10.1274/jmor.33.101
Received: 30 March 2016; Accepted: 1 May 2016; Published: 1 October 2016
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