Translator Disclaimer
1 April 2018 Histomorphological Aspects of the Ovarian Cortex Regarding Ovarian Reserve and Local Pelvic Inflammation
Michio Kitajima, Naoko Murakami, Ken Taniguchi, Yuriko Kitajima, Ozora Tsukamoto, Kiyonori Miura, Hideaki Masuzaki
Author Affiliations +
Abstract

The ovaries of women of reproductive age may show specific histological structures that may relate to the maintenance of primordial follicles and the regulation of early follicular development, which are keys to understanding the dynamics of ovarian reserve. The pelvic environment of women is frequently exposed to physiological or pathological inflammatory stimuli. Endometriosis is a disorder that should be viewed as a chronic inflammatory disease manifested by pelvic pain and infertility. Inflammation surrounding the normal ovarian cortex may alter the histological structure which possesses primordial and early growing follicles. Fibrotic changes in histological niches in the nest of primordial follicles may provoke activation of dormant follicles and concomitant atresia. Along with decline in AMH, which is produced by early growing follicles, fibrotic changes may accelerate the demise of primordial follicles which has been described as “burn-out by inflammation”. As a result, women with endometriosis may suffer from diminished ovarian reserve, a possible cause of endometriosis-related infertility.

©2018 Japan Society for Ova Research
Michio Kitajima, Naoko Murakami, Ken Taniguchi, Yuriko Kitajima, Ozora Tsukamoto, Kiyonori Miura, and Hideaki Masuzaki "Histomorphological Aspects of the Ovarian Cortex Regarding Ovarian Reserve and Local Pelvic Inflammation," Journal of Mammalian Ova Research 35(1), 21-26, (1 April 2018). https://doi.org/10.1274/jmor.35.21
Received: 26 December 2017; Accepted: 1 February 2018; Published: 1 April 2018
JOURNAL ARTICLE
6 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top