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1 May 2002 Toxic Effect of Aliphatic Alcohols Against Susceptible and Permethrin-Resistant Pediculus humanus capitis (Anoplura: Pediculidae)
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Abstract

The effectiveness of 1-octanol, 1-nonanol, 1-decanol, 1-undecanol, and 1-dodecanol was evaluated by immersion method against susceptible and permethrin-resistant head lice, Pediculus humanus capitis De Geer, from Buenos Aires, Argentina. All the tested alcohols showed knockdown effect at 10 min and mortality 18 h after treatment. The highest activity was found for the 1-dodecanol (KC50 2.55%, LC50 2.28%) and the lowest for 1-octanol (KC50 8%, LC50 4.46%). The toxicity to the head lice systematically increased with the increase in carbon atoms in the n-aliphatic alcohol moiety, and with the octanol:water coefficient (r2 = 0.94). The pediculicidal activity of 1-dodecanol was not correlated with resistance to permethrin, because no significant difference was observed between toxicity parameters in the susceptible (MAR) and the permethrin-resistant populations which had different resistant levels (RR 5.77× for E49 population, RR 9.5× for HL population and RR > 35.3× for GH population). The pediculicidal effect of aliphatic alcohols demonstrated in this study and the lack of correlation with the permethrin resistance may prove to have a practical value for use in susceptible and permethrin-resistant head lice control.

G. Mougabure Cueto, P. Gonzalez Audino, C. V. Vassena, M. I. Picollo, and E. N. Zerba "Toxic Effect of Aliphatic Alcohols Against Susceptible and Permethrin-Resistant Pediculus humanus capitis (Anoplura: Pediculidae)," Journal of Medical Entomology 39(3), 457-460, (1 May 2002). https://doi.org/10.1603/0022-2585-39.3.457
Received: 5 September 2001; Accepted: 1 November 2001; Published: 1 May 2002
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