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1 November 2006 Selection of Insensitive Acetylcholinesterase as a Resistance Mechanism in Aedes aegypti (Diptera: Culicidae) from Santiago de Cuba
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Abstract

A sample of Aedes aegypti (L.) (Diptera: Culicidae) from Santiago de Cuba, Cuba, with a high level of propoxur resistance compared with the reference susceptible Rockefeller strain (12.60× at the 50% lethal concentration [LC50] and 18.08 at the 90% lethal concentration [LC90]), with a 4.3% frequency of insensitive acetylcholinesterase (AChE) frequency, was subjected to propoxur selection for 13 successive generations to increase the frequency of this resistance mechanism in Ae. aegypti. High resistance to propoxur was developed during this selection (41.73-fold), and the frequency of insensitive AChE mechanism was increased 13.25-fold. Other mechanisms (overproduced esterases, glutathione transferases, or monooxygenases) were not detected in the propoxur-selected strain. The selection of an insensitive AChE resistance mechanism in Ae. aegypti has important implications and will be a valuable resource for genetic studies and molecular characterization of the ace gene mutation(s) associated with insecticide resistance in Ae. aegypti.

Juan Bisset, María M. Rodríguez, and Ditter Fernández "Selection of Insensitive Acetylcholinesterase as a Resistance Mechanism in Aedes aegypti (Diptera: Culicidae) from Santiago de Cuba," Journal of Medical Entomology 43(6), 1185-1189, (1 November 2006). https://doi.org/10.1603/0022-2585(2006)43[1185:SOIAAA]2.0.CO;2
Received: 8 August 2005; Accepted: 27 January 2006; Published: 1 November 2006
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