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1 July 2009 Permethrin Induces Overexpression of Cytochrome c Oxidase Subunit 3 in Aedes aegypti
Julia W. Pridgeon, James J. Becnel, Gary G. Clark, Kenneth J. Linthicum
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Abstract

Using quantitative polymerase chain reaction (QPCR), the relative transcriptional levels of cytochrome c oxidase subunit 3 (COS) were studied in Aedes aegypti in response to treatment with acetone, permethrin, and fipronil. The transcriptional levels of CO3 were significantly (P < 0.05) higher in acetone-treated Ae. aegypti compared with that in untreated samples. Using ribosomal L24, heat shock protein (HSP), and actin as reference genes, relative transcription levels of CO3 in acetone-treated Ae. aegypti were 2.88 ± 0.38-, 2.60 ± 0.60-, and 3.24 ± 0.70-fold higher, respectively, compared with that in untreated mosquitoes. Transcriptional levels of CO3 were induced significantly higher (6.54 ± 1.22-, 4.62 ± 0.74-, and 9.47 ± 3.71-fold, respectively) by permethrin at LD10 compared with acetone (P < 0.05). Taken together, our results suggest that overexpression of CO3 is tightly regulated in Ae. aegypti in response to xenobiotic treatment.

Julia W. Pridgeon, James J. Becnel, Gary G. Clark, and Kenneth J. Linthicum "Permethrin Induces Overexpression of Cytochrome c Oxidase Subunit 3 in Aedes aegypti," Journal of Medical Entomology 46(4), 810-819, (1 July 2009). https://doi.org/10.1603/033.046.0411
Received: 9 October 2008; Accepted: 30 March 2009; Published: 1 July 2009
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KEYWORDS
Aedes aegypti
cytochrome c oxidase
fipronil
overexpression
permethrin
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