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1 September 2011 Possible Implication of the Genetic Composition of the Lutzomyia longipalpis (Diptera: Psychodidae) Populations in the Epidemiology of the Visceral Leishmaniasis
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Abstract

Lutzomyia longipalpis (Diptera: Psychodidae) is the principal vector of American visceral leishmaniasis. Several studies have indicated that the Lu. longipalpis population structure is complex. It has been suggested that genetic divergence caused by genetic drift, selection, or both may affect the vectorial capacity of Lu. longipalpis. However, it remains unclear whether genetic differences among Lu. longipalpis populations are directly implicated in the transmission features of visceral leishmaniasis. We evaluated the genetic composition and the patterns of genetic differentiation among Lu. longipalpis populations collected from regions with different patterns of transmission of visceral leishmaniasis by analyzing the sequence variation in the mitochondrial cytochrome b gene. Furthermore, we investigated the temporal distribution of haplotypes and compared our results with those obtained in a previous study. Our data indicate that there are differences in the haplotype composition and that there has been significant differentiation between the analyzed populations. Our results reveal that measures used to control visceral leishmaniasis might have influenced the genetic composition of the vector population. This finding raises important questions concerning the epidemiology of visceral leishmaniasis, because these differences in the genetic structures among populations of Lu. longipalpis may have implications with respect to their efficiency as vectors for visceral leishmaniasis.

© 2011 Entomological Society of America
Leonardo de Souza Rocha, Aloisio Falqueto, Claudiney Biral Dos Santos, Gabriel Grimaldi, and Elisa Cupolillo "Possible Implication of the Genetic Composition of the Lutzomyia longipalpis (Diptera: Psychodidae) Populations in the Epidemiology of the Visceral Leishmaniasis," Journal of Medical Entomology 48(5), 1016-1022, (1 September 2011). https://doi.org/10.1603/ME10249
Received: 17 November 2010; Accepted: 1 June 2011; Published: 1 September 2011
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