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1 March 2012 Mosquitocidal Properties of Natural Product Compounds Isolated from Chinese Herbs and Synthetic Analogs of Curcumin
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Abstract

Because of resistance to current insecticides and to environmental, health, and regulatory concerns, naturally occurring compounds and their derivatives are of increasing interest for the development of new insecticidal compounds against vectors of disease-causing pathogens. Fifty-eight compounds, either extracted and purified from plants native to China or synthetic analogs of curcumin, were evaluated for both their larvicidal activity against Aedes aegypti (L.) and their ability to inhibit binding of cholesterol to Ae. aegypti sterol carrier protein-2 in vitro. Of the compounds tested, curcumin analogs seem especially promising in that of 24 compounds tested five were inhibitors of Ae. aegypti sterol carrier protein-2 with EC50 values ranging from 0.65 to 62.87 µM, and three curcumin analogs exhibited larvicidal activity against fourth instar Ae. aegypti larvae with LC50 values ranging from 17.29 to 27.90 µM. Adding to the attractiveness of synthetic curcumin analogs is the relative ease of synthesizing a large diversity of compounds; only a small fraction of such diversity has been sampled in this study.

© 2012 Entomological Society of America
David M. Anstrom, Xia Zhou, Cody N. Kalk, Baoan Song, and Que Lan "Mosquitocidal Properties of Natural Product Compounds Isolated from Chinese Herbs and Synthetic Analogs of Curcumin," Journal of Medical Entomology 49(2), 350-355, (1 March 2012). https://doi.org/10.1603/ME11117
Received: 9 June 2011; Accepted: 1 December 2011; Published: 1 March 2012
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