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25 August 2016 Toxicity and Larvicidal Activity of Podophyllum-Based Lignans Against Aedes aegypti (Diptera: Culicidae)
Marise Maleck, Priscila de Oliveira Hollanda, Michele Teixeira Serdeiro, Renata Oliveira de Araújo Soares, Nildimar Alves Honório, Cláudia Gontijo Silva
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Abstract

Aedes aegypti L. (Diptera: Culicidae) is a mosquito species that has adapted to urban environments and is the main vector of dengue viruses. Because of the increasing incidence of dengue, a more environmentally acceptable insecticide needs to be found. Natural products have been and continue to be an important source of leading compounds that can be modified in order to develop new drugs. The lignan family of natural products includes compounds with a diverse spectrum of biological activity. Podophyllotoxin and its related lignans represent an exciting class of natural products that can be targeted at different types of biological activity and are therefore worth exploring further. This study had the aim of evaluating the larvicidal activity of an ethanolic extract from the rhizomes and roots of Podophyllum hexandrum (PM-3) and its isolated lignans, podophyllotoxone (1) and desoxypodophyllotoxin (2), on the larvae of the mosquito vector Ae. aegypti. The PM-3 extract and the compounds (1) and (2) were dissolved in a mixture of acetone and dimethylsulfoxide at final concentrations of 1, 10, 30, 50, 100, and 200 μg/ml. After dilution, the solutions were applied (μg/ml) to the larvae-rearing medium. Overall, the ethanolic extract from the rhizomes and roots of P. hexandrum and the compounds (1) and (2) showed larvicidal activity against the larvae of Ae. aegypti. According to the results from this study, it can be concluded that podophyllotoxone (1) and desoxypodophyllotoxin (2) exhibited significant toxicity toward Ae. aegypti larvae.

© The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com
Marise Maleck, Priscila de Oliveira Hollanda, Michele Teixeira Serdeiro, Renata Oliveira de Araújo Soares, Nildimar Alves Honório, and Cláudia Gontijo Silva "Toxicity and Larvicidal Activity of Podophyllum-Based Lignans Against Aedes aegypti (Diptera: Culicidae)," Journal of Medical Entomology 54(1), 159-166, (25 August 2016). https://doi.org/10.1093/jme/tjw130
Received: 6 April 2016; Accepted: 29 July 2016; Published: 25 August 2016
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KEYWORDS
Aedes aegypti
larvicidal activity
lignans
Podophyllum hexandrum
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