Larval therapy (LT) is a therapeutic modality that uses larvae of necrophagous flies for the treatment of wounds. The use of this therapy presents several benefits, due to the action of the larvae that remove necrotic tissue selectively, exercising antimicrobial action, and promoting healing. There are situations in which LT proves to be the only or the best alternative for the patient, such as wounds infected by multidrug-resistant microorganisms or when treatment difficulties may lead to an indication for amputation. The purpose of this study was to compare the efficiency of LT, using larvae of Chrysomya megacephala, with that of antibiotic therapy in the treatment of cutaneous wounds infected with Pseudomonas aeruginosa. Twenty-four rabbits were used to perform the experiment, distributed in four groups: group 1, induced wound without bacterial infection; group 2, induced wound with bacterial infection; group 3, induced wound with bacterial infection and antibiotic therapy; group 4, induced wound with bacterial infection and LT. The macroscopic, microscopic, and statistical analyses indicated that LT was as effective as antibiotic therapy in wound healing.
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10 December 2020
Evaluation of Larval Therapy Compared to Antibiotic Therapy in the Treatment of Skin Wounds in Rabbits
Luciano Antunes Barros,
Lucas Xavier Sant'Anna,
Claudia Soares Lessa,
Valéria Magalhães Aguiar Coelho,
Mariana dos Passos Nunes,
Cláudio Maurício Vieira de Souza,
Maria Carmela Kasnowski Holanda Duarte,
Ana Beatriz Monteiro Fonseca,
Cláudio Alessandro Massamitsu Sakamoto,
Juliana da Silva Leite
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Journal of Medical Entomology
Vol. 58 • No. 2
March 2021
Vol. 58 • No. 2
March 2021
Chrysomya megacephala
Fly
healing
larva
larval therapy
