We evaluated the relative effectiveness of the natural product acaricide Essentria IC³ and the entomopathogenic fungal acaricide BotaniGard ES to suppress host-seeking Ixodes scapularis Say and Amblyomma americanum (L.) nymphs when applied with low-pressure backpack and high-pressure sprayers. Essentria IC³ applied by backpack sprayer out-performed high-pressure applications, while the opposite was true for treatments with BotaniGard ES. We were unable to demonstrate consistently greater efficacy using high-pressure applications, and neither of the acaricides or application methods provided substantial (>90%) levels of control at 7 days postapplication.